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lipid A biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
ADP-L-glycero-D-manno-heptose + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose <=> ADP + heptosyl-(1,3)-heptosyl-KDO2-lipid_A 2.4.99.B7

palmitoleoyl-[acyl-carrier_protein] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid_IVA <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(palmitoleoyl)-lipid_IVA + [acyl-carrier_protein] 2.3.1.242 Kdo2-lipid IVA palmitoleoyltransferase

UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl_1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl_beta-phosphate 2.4.1.182 lipid-A-disaccharide synthase

UDP-glucose + heptosyl-(1,3)-heptosyl-KDO2-lipid_A <=> UDP + glucosyl-(1,3)-heptosyl-(1,3)-heptosyl-KDO2-lipid_A 2.4.1.B64

UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine + H2O <=> 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl_1-phosphate + UMP 3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase

ADP-L-glycero-D-manno-heptose + Kdo2-lipid_A <=> ADP + Hep2-Kdo2-lipid_A 2.4.99.B7

(3R)-3-hydroxymyristoyl-[acyl-carrier_protein] + UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine <=> UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine + [acyl-carrier_protein] + H+ 2.3.1.191 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl_beta-phosphate + ATP <=> H+ + lipid_IVA_(E._coli) + ADP 2.7.1.130 tetraacyldisaccharide 4'-kinase

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